A postdoctoral position in genome instability in mammalian eggs in the Hoffmann laboratory at the Center for Chromosome Stability, Department of Cellular and Molecular Medicine

The Hoffmann laboratory in the Center for Chromosome Stability (www.ccs.ku.dk) at the Department of Cellular and Molecular Medicine (www.icmm.ku.dk), University of Copenhagen, is seeking two postdoctoral fellows. The CCS is a center of excellence funded by the Danish National Research Foundation to addresses basic research questions in chromosome biology and translates promising basic research results into new strategies and targets for the development of new therapies for cancer and reproductive health. The successful applicant(s) will join a group of ambitious and dedicated scientists studying the mechanisms by which the ovaries age.



Start date: January 1st, 2025, or after agreement

Duration: 1 year and 8 months
Weekly working hours: 37



Our group and research – The Hoffmann laboratory investigates the role of regulation of genome instability in mouse and human eggs and embryos. This project is to study the function of PICH helicase and how this influences oocyte maturation and aneuploidy. The lab consists of 15 students and postdocs working on various aspects of women’s reproduction, fertility and genetics. You will be part of the Novo Nordisk Foundation funded Distinguished Investigator award, which uses cross-disciplinary approaches to understand aneuploidy and regulation of fertility.



You will be responsible for using human and mouse oocytes as well as mouse genetics to elucidate the mechanisms of PICH. This will be integrated with human genomics as well as clinical datasets.



The Department
The Department of Cellular and Molecular Medicine focuses on basic cellular and molecular biological processes, their regulation and their significance for cell function, interaction and organization in tissues. The Department offers comprehensive undergraduate and graduate teaching programs spanning cell biology, genetics and basic human biology, including chemistry, biochemistry, physiology, as well as anatomy. You can read more about the department at www.icmm.ku.dk.



Your job
We are a motivated postdoctoral fellows with a background in molecular biology. The project will use data integration from large human genomics datasets and you will be expected to have a broad, yet mechanistic approach, to develop and use appropriate cell line, organoid and mouse models. You will be expected to be responsible for project management, administrative tasks, supervision of personnel, and data maintenance. Laboratory tasks include working with cell lines and ovarian organoid models, human and mouse oocytes, and mouse models.

Your responsibilities will primarily consist of:

• research, including publication/academic dissemination duties
• research-based teaching
• sharing knowledge with society
• participation in formal teaching and pedagogical training

Profile
We are looking for highly motivated and enthusiastic scientists with the following competencies and experience:

Key experience and skills for the assessment of applicants:

• You should hold a PhD degree in genetics, cell biology, molecular biology, or a related discipline.
• Display a high level of proficiency in molecular biology and tissue culture.
• Data management skills and experience in scientific collaborations.
• You must have experience in handling mouse and/or human oocytes.
• It is an advantage but not a requirement to be accredited with the Federation of European Laboratory Animal Science Associations (FELASA ABD).
• Experience with research in PICH helicase or similar DNA repair proteins
• Have an interest in research-led teaching experience pre- and postgraduate teaching experience within genetics, cell biology, molecular biology, or a related discipline.
• Should have an interest in developing their own teaching skills and supervising bachelor and master degree student projects.
• Experience in participating in grant applications for research funds, including but not limited to fellowships.
• Peer-reviewed publications in recognised journals.
• Excellent English skills, both written and oral.

Place of employment
The place of employment is at DNRF Center for Chromosome Stability (CCS), Faculty of Health and Medical Sciences, University of Copenhagen. The CCS is part a greater research environment at The Department of Cellular and Molecular Medicine (ICMM) aiming to produce research with high international impact. The research focus is on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. We offer creative and stimulating working conditions in dynamic and international research environment. You can read more about the CCS here: www.ccs.ku.dk.



Terms of employment
The average weekly working hours are 37 hours per week.



The position is a fixed-term position limited to a period of 1 year and 8 months. The start date is January 1st, 2025, or after agreement.

Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at 35,500 DKK/approx. 4,750 EUR (April 2024 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.



Foreign and Danish applicants may be eligible for tax reductions if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.



Questions
For further information please contact Eva Hoffmann [email protected]; www.sund.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (Max. one page)
2. CV incl. education, work/research experience, language skills and other skills relevant for the position
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications
5. Teaching portfolio

Deadline for applications: 31st of October, 2024; 23.59pm CET



We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.



The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/



The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.



Interviews are expected to be held in November 2024.

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.