PhD Position: Transforming Colorectal Cancer Prevention through Microbiome Modulation Center for Surgical Science (CSS), Zealand University Hospital, Køge

We are excited to offer a 3-year PhD position starting in February 2025 or as early as possible thereafter, focusing on the groundbreaking ENABLED project. Join us in pioneering innovative, personalized approaches to colorectal cancer prevention by exploring the modulation of the intestinal microbiome to reduce polyp recurrence and colorectal cancer risk.

About CSS and Our Research
CSS is a multidisciplinary research hub uniting experts in medicine, molecular biology, data science, bioinformatics, and more. Our mission is to revolutionize colorectal cancer care, reduce complications, and improve patient outcomes. Through advanced research methodologies, we aim to leverage cutting-edge data and technologies to deliver individualized care.

About the ENABLED Project
The ENABLED study is a paradigm-shifting project in colorectal cancer prevention, addressing the potential of microbiome modulation to reduce polyp recurrence. Key aspects of the study include:

• International Multicenter Collaboration: Investigating the effects of local antibiotic applications (metronidazole and fosfomycin) during colonoscopy on polyp recurrence and new polyp development.
• Targeting Dysbiosis: Examining the role of microbiome imbalance in the development of dysplasia and polyposis, and testing if local microbiome modulation can reverse this state.
• Comprehensive Translational Research: Analyzing the bacterial tumor microenvironment and biomarkers linked to dysbiosis, advancing knowledge in colorectal cancer prevention.

This project has the potential to redefine prevention strategies by addressing the root causes of polyp formation and recurrence.

Your Role as a PhD Student
As a PhD student, you will:

• Be immersed in cutting-edge research at the Department of Surgery, Zealand University Hospital, Køge.
• Collaborate with a dedicated multidisciplinary team conducting the ENABLED RCT.
• Design and execute study protocols, ensuring adherence to trial standards.
• Analyze patient data to uncover relationships between microbiome modulation, polyp recurrence, and colorectal cancer prevention.
• Participate in translational research to identify biomarkers predictive of polyp recurrence.
• Receive structured training and mentoring while contributing to high-impact publications.

Qualifications
We are seeking a motivated medical doctor or biologist with:

• A Master’s degree in Medicine, Biology, or a related field.
• Interest in oncology, microbiome research, and clinical trials.
• Preferably, prior publications in peer-reviewed journals.
• Strong analytical, communication, and collaborative skills.
• Proficiency in English (Danish proficiency is a plus but not mandatory).
• Experience in clinical research is advantageous.

How to Apply
Your application must include:

• A motivation letter.
• A detailed CV.
• Diplomas and documentation of education.
• Proof of relevant research experience and/or publications.

Application Deadline
Submit your application no later than 15 January 2024.

Terms of Employment
This is a full-time position (37 hours/week) with a guaranteed salary during employment. Enrollment as a PhD student at the Graduate School, Faculty of Health and Medical Sciences, University of Copenhagen, is mandatory, with tuition fees covered by Region Zealand. Medical doctors will be employed under the collective agreement of the Danish Medical Association.

Questions?
For further information, please contact Professor Ismail Gögenur at [email protected], phone +45 26336426.

Learn more about us: Center for Surgical Science

Join us in shaping the future of colorectal cancer prevention and making a lasting impact on patients' lives.

Om os

Den 1. januar 2024 fusionerede Sjællands Universitetshospital (SUH) med Nykøbing F. Sygehus (NFS). Som et af Danmarks største akutsygehuse driver og udvikler vi sygehusene i Køge, Roskilde og Nykøbing F. Vi har aktivitet på alle regionens sygehuse, og vi betjener alle regionens patienter med specialiserede sundhedsydelser samt tilbyder sundhedsydelser inden for 32 forskellige lægelige specialer.

Som Danmarks seneste universitetshospital søger vi at omdefinere tilgangen til, hvordan sundhedsfaglige ydelser leveres i regionen. Vi stræber efter at sikre lige sundhedstilbud for alle. Med øget fokus på uddannelse, forskning og innovation arbejder vi ud fra tankesættet om at bygge bro over afstande, etablere tværfaglige fællesskaber og bringe specialiseret behandling tættere på borgerne.

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