Postdoc in Cancer Epigenetics

Applications are invited for a position of postdoc in Cancer Epigenetics in the laboratory of DNRF Chair and Novo Nordisk Faculty Professor Vijay Tiwari (https://www.tiwarilab.org/ ). 

The position is available - initially for six months - from January 1, 2025, or as soon as possible thereafter - with the possibility of extension for three years.

The postdoc will lead research on gene regulatory mechanisms underlying cancer metastasis and drug resistance and will support Professor Tiwari in smooth running of the laboratory at various levels. The group employs cutting-edge molecular biology, epigenetics and genomics tools in combination with computational biology approaches to generate comprehensive models of gene regulation during carcinogenesis.

To learn more, please refer to the selected publications from the Tiwari lab:

Science Advances, 2024, Jun 7;10(23):eadn1640; EMBO Mol Medicine, 2024, Apr; 16(4):823-853; Nature Communications, 2024, 11;15(1):1870;  npj Precision Oncology, 2024, Mar 12;8(1):64; Nature Cell Biology, 2022, 24, 1265–1277; Genes & Development, 2020, Sep; 34(17-18):1190-1209; Nature, 2019, Mar; 567(7746):113-117; Cell Stem Cell, 2018, Oct 4; 23(4):557; Nature Communications, 2017 Nov 15;8(1):1523; The EMBO Journal, 2016 Jan 4;35(1):24-45; J Cell Science, 2015 Dec 1;128(23):4380-94; The EMBO Journal, 2015 Aug 13;34(16):2162-81; Genome Research, 2015 Sep;25(9):1309-24; Nature Communications, 2013, Sep 27; 4:2478; Cancer Cell, 2013, 23, 768-783; PNAS, 2012 Apr 17;109(16): E934-43; Nature Genetics, 2012 Jan; 18;44(1):94-100;  Nature, 2011 Dec 14;480 (7378):490-5.     

You will

• Lead research on gene regulatory mechanisms in cancer metastasis and chemoresistance
• Employ state-of-the-art methods in epigenetics and gene regulation including histone modification, transcription factor binding and chromatin accessibility assays
• Design research projects and support in establishing complex molecular biology protocols 
• Perform in vitro and in vivo (animal models) experiments as necessary
• Support research and development activities within the group
• Support the group leader in everyday routines including training new group members
• Maintain accurate and detailed records of all research activities within the group
• Collaborate with internal and external partners
• Engage in teaching as required
• Conduct collaborative research and interact with a broad range of colleagues and researchers 

Essential Qualifications            

• PhD in molecular biology, epigenetics, chromatin biology, genomics, cancer biology, biochemistry, developmental biology or related areas. 
• At least one first-author publication, accepted or submitted
• Strong analytical, organizational, and record-keeping skills
• Proficient computer skills, including MS Office and research software programs 
• Interest in working in a multidisciplinary and multicultural team 
• Willing to collaborate with internal and external collaborators as well as support group members

Desired Qualifications            

• Basic understanding of cancer biology and gene regulation
• Conceptual grip on cancer genetics, epigenetics and gene regulation
• Experience in cell culture as well as basic and advanced molecular biology techniques
• Familiarity with organoids\spheroids and mouse models
• Prior experience with perturbation-based functional analysis (e.g. shRNA, CRISPR-Cas9).
• Familiarity with drug sensitivity assays and screening
• Expertise in tissue sectioning, immunostaining and advanced imaging e.g. confocal microscopy
• Basic understanding of Bioinformatics would be an advantage

The Department of Molecular Medicine (IMM)

IMM aims to generate new knowledge on the function of the human body and disease mechanisms, thereby contributing to improved human health. IMM hosts an interdisciplinary group of experts in cancer biology and is in close proximity to the experts in genomics, proteomics and chromatin biology. Such a promising environment elicits translational collaborations with clinical practice and research toward understanding mechanisms underlying the pathophysiology of various human diseases.

We offer 

• The possibility to engage in high-impact, multidisciplinary research
• A stimulating, diverse and international research environment 
• An initial contract for six months, with the possibility of extension for three years
• Advanced training opportunities 
• Highly motivated research team and international collaborations
• Access to state-of-the-art equipment and facilities
• A supportive scientific and social network, including mentoring and career development
• A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.)
• Support with practical, social, and legal aspects (e.g. housing, visa, tax etc.) through our international staff office (ISO) and the department

Further information

Further information can be obtained by e-mail to Professor Vijay Tiwari at [email protected]

Application deadline

November 30, 2024, at 23.59 hrs. CET

Salary and terms of employment

The successful applicant for the postdoc position will be employed in accordance with the agreement between the Danish Ministry of Finance and AC (the Danish Confederation of Professional Associations).

Application

Applications must be submitted electronically using the link “Apply now” - see below.

We strongly recommend that you read How to apply for a position at SDU before you apply.

Only applications written in English will be accepted for evaluation.

The application must include (as PDF files) (please note that the application (the motivation letter) and CV must not exceed 10 MB in total):

The application must contain (as pdf-files):

• a motivation letter
• a detailed CV including contact information
• degree certificates (inclusive of Ph.D.-diploma)
• a complete and numbered list of publications

Please note that all the above-mentioned information must be included in the application. Incomplete applications will not be assessed.

If you experience technical problems, you must contact [email protected].   

Applications may be shortlisted. 

Living and working in Denmark

Foreign applicants will be offered Danish language training  as part of the employment. 

The International Staff Office (ISO) at SDU provides a variety of services for new employees, guests and people who are considering applying for a job at the University of Southern Denmark.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.