Postdoc position in Molecular Biology at BRIC

Faculty of Health and Medical Sciences
University of Copenhagen



We are looking for a highly motivated postdoc to join the Cvejic Lab with the commence date of January 15th 2025 or soon thereafter.

Information on the department can be found at: BRIC – University of Copenhagen (ku.dk)

Our research
We are a team of highly skilled researchers collaborating with international partners from industry and other universities to perform exciting interdisciplinary science using cutting-edge experimental and computational technologies.

The research in our group can be broadly divided into two main areas:

Our basic research projects using human haematopoietic cells aim to dissect dynamics and cellular programmes active during human blood lineage development and to decipher how haematopoietic differentiation pathways are influenced by different microenvironments.

In our translational research projects, we use various state-of-the-art single cell sequencing techniques to analyse cancer patient samples, investigating the influence of the tumour microenvironment in the context of pathological differentiation of immune cells.

Your job
You will have a strong scientific background in cell biology and epigenetics, and you will be able to demonstrate critical thinking within and beyond these areas. You will be hard working, passionate about science, and keen to learn and improve skills within a supportive research environment.

You will be involved in a project that aims to comprehensively dissect the molecular underpinnings of the haematopoietic stem cell state. To achieve this, the project will implement a CRISPR-Cas9 screen to interrogate a large number of targets and reveal the key factors that regulate important stem cell functions. The initial screen will be followed by extensive functional characterisation of candidates of interest, with the goal of gaining novel mechanistic insight into blood stem cell regulation.

You will be part of a multidisciplinary team and will be tasked with proactively seeking and maintaining appropriate collaborations. You will be expected to contribute to and support the ongoing research projects in the group on an ad-hoc basis when needed, working closely with biologists, clinicians and bioinformaticians within and outside the group to accomplish scientific objectives; disseminate your expertise to new lab members, participate in grant writing and be actively involved in scientific discussions within the lab.

Profile
We are looking for a highly motivated and enthusiastic postdoc with the following competencies and experience:

Essential experience and skills

• A PhD in life sciences or related
• Extensive experience in cell biology and epigenetics
• Extensive experience in molecular biology techniques and cell culture
• Extensive experience in flow cytometry
• Extensive experience in gene editing by CRISPR-Cas9, preferably in a screening setup
• An excellent research and publication track record
• Highly organised
• Excellent ability to effectively prioritise, multi-task and work independently
• Excellent English skills, written and spoken

Desirable experience and skills

• Experience in working with primary cells and patient-derived material
• Experience in single cell genomics techniques (RNA-Seq, Multiomics)
• Experience in tissue dissection and histology

Place of employment
The place of employment is at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and core facilities Core Facilities – University of Copenhagen (ku.dk).

Terms of employment
The average weekly working hours are 37 hours per week.

The position is a fixed-term position limited to a period of 3 years. The starting date is the 15th of January 2025 or soon thereafter.

Employment will be in accordance with the provisions of the collective agreement between the Danish Ministry of Taxation and AC (the Danish Confederation of Professional Associations). The monthly salary will be based on the number of years of work experience (seniority) with the possibility to negotiate a salary supplement based on prior experiences and qualifications. The employer will pay an additional 17.1 % to your pension fund.

Questions
For further information, please contact Laboratory Coordinator Ulf Tiemann: [email protected]

https://www.bric.ku.dk/research-groups/Research/cvejic-group/

Application
Your application should in English include:

• Letter of application addressing the requirements (max. one page).
• Curriculum Vitae
• A certified/signed copy of certificate(s) of education

Please submit your application by clicking on “Apply Now” below. Only online applications will be accepted.

Application deadline: 31.10.2024, 23.59 CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

Interviews are expected to be held in November.

The University of Copenhagen wishes to reflect the diversity of society and encourages all qualified candidates to apply regardless of personal background.