Postdoc position in experimental hematology to study normal and malignant hematopoietic stem cell biology

The Porse group at the Finsen Laboratory/BRIC at University of Copenhagen is seeking a highly motivated postdoc to work on hematopoietic stem cell biology.

Our research/The group

The Porse group (Finsen Laboratory/BRIC) has a diverse and stimulating environment and we focus our research on elucidating mechanisms governing normal and malignant haematopoiesis with special emphasis on the behaviour of hematopoietic stem cells (HSCs) during adult haematopoiesis and leukemic stem cells (LSCs) in acute myeloid leukaemia. To this end, we employ mouse models of human AML, mouse knockout lines of putative HSC/LSC regulators, primary patient material and a broad range of genome-wide approaches and single cell analyses incl. cutting edge single cell proteomics.

The Porse group is affiliated with the Finsen Laboratory at Rigshospitalet as well as with BRIC at the University of Copenhagen.

Project/The research project(s)

The successful candidate will join an international and interdisciplinary research group working on various aspects of normal and malignant hematopoietic stem cell biology including associated diseases such as acute myeloid leukemia. The candidate(s) will use advanced CRISPR-Cas9 gene editing technologies in primary human and murine hematopoietic stem cells to functionally assess novel regulators of normal and malignant hematopoietic stem cell biology. These regulators were identified by advanced proteomics technologies and their expression patterns are to a large degree governed by non-transcriptional mechanisms. There will be a large degree of freedom for the candidate(s) to shape and drive the research projects forward.

Start: 1 April 2025 or soon thereafter

Duration: 3 years

Qualifications

We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:

• A PhD in life sciences or equivalent research experience.
• Strong documented research experience and expertise in either single-cell technologies, experimental mouse work, biochemistry, advanced flow cytometry, genome-wide approaches (ChIP-seq, Chromatin Conformation Capture, etc), CRISPR technologies or functional haematopoiesis.
• Candidates with combined experiences are particularly encouraged to apply.
• Good organizational skills and a detail-oriented structured approach to work tasks.
• Collaborative skills.
• Excellent English skills written and spoken.

For further information regarding the position, please contact Professor Bo Porse on e-mail: [email protected]

Place of employment

The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and several core facilities (NGS, single cell and spatial aspects, high-throughput robotics tec.) shared between the 26 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited international speakers. A young researchers club (ASAP), our own PhD programme (MoMeD) and our own Postdoc Career Programme. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/

Please read more about the Porse group and BRIC research on http://www.bric.ku.dk/

Terms of salary and employment

The employment as postdoc is a full time and fixed-term position for 3 years and the starting date for employment is 1 April 2025 or soon thereafter.

Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at DKK 38,500/approx. EUR 5,150 (April 2024-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Application

Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on http://www.bric.ku.dk/jobs/. The application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.

Application deadline: 8 December 2024, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

BRIC and the University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.