This is a 3-year PhD position, that is part of a European Doctoral Network (DN) program entitled “ PersonalIzed medicine in Chronic KidnEy Disease (PICKED) ” that involves 10 research centers from France, Austria, Spain, Greece, Germany, Denmark and Estonia.
The PhD position “DC6” is hosted at Steno Diabetes Center Copenhagen, Denmark.
The PICKED Consortium / Background
Kidney diseases both chronic (CKD) and acute (AKI) should be considered as a priority, but also a challenge, for Public Health Policies as they concern > 850 million persons in the world. The major urgent needs that have been identified over the last years include i) early detection in “at-risk” patients of CKD, ii) detection and prediction of CKD progression/complications and iii) personalized treatment avoiding over- or unnecessary-treatment, that collectively contribute to the adoption of Personalized Medicine (PM) in CKD. To address such ambitious challenges, it is essential to embark and train professionals to identify these issues. Constituting a network of 10 PhD students, 6 public laboratories, 4 research and development companies and several associated partners, the PICKED consortium will work on different aspects of PM aiming to significantly reduce the burden of CKD including: early detection of CKD and its progression; personalized drug and dialysis treatment and the social-economic impact of PM in CKD.
Objectives of the PhD
The overall objective of the PhD project is to investigate urinary peptide patterns and the effect of different contemporary treatments, to increase understanding of specific beneficial pathways that treatments affect and explore kidney-specific mechanisms through which these compounds act.
The main objectives of the PhD will be:
Methods
The PhD student will mostly work on
Expected Results
Further advancement of the understanding of dynamics and the mechanisms of current CKD treatment in diabetes. The data will enable more detailed assessment of molecular pathophysiology (due to the multiparametric approach) and linking drug response to molecular mechanisms in diabetic CKD (collaboration with DC2).
Supervision
Planned secondments
Mosaiques Diagnostics, Harald Mischak, to learn and understand CE-MS analysis of urinary proteomics; 2) University of Heidelberg, Paul Perco, bioinformatic analysis, linking biomarkers to disease pathophysiology and training in especially vector.
Required skills and education
Marie Skłodowska-Curie ITN rules
Benefits
How to apply
You should send your candidacy by email to including the following information:
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